Serological and structural properties of Mason-Pfizer monkey virus isolated from the mammary tumor of a Rhesus monkey.
نویسندگان
چکیده
We describe here serological and structural properties of a virus, Mason-Pfizer Monkey Virus (M-PMV), isolated from a simian mammary tumor. This virus is morphologically similar to the known oncogenic RNA viruses (oncornaviruses). It has a 60-70S RNA, and its replication is inhibited by actinomycin. Antisera prepared against the virus isolated by density-gradient centrifugation identify at least two viral structural antigens. Immunodiffusion studies show that this virus is serologically unrelated to three types of simian foamy viruses, visna virus, and the known oncornaviruses. Immunofluorescence reveals that the structural proteins of the virus are synthesized cytoplasmically. Although M-PMV productively infects human cells in vitro, serological analysis does not show the presence of M-PMV antigens in human neoplasia.
منابع مشابه
Ultrastructural comparison of a virus from a Rhesus-monkey mammary carcinoma with four oncogenic RNA viruses.
The ultrastructure and morphogenesis of Mason-Pfizer monkey virus, isolated from a mammary carcinoma in a Rhesus monkey, was compared with those of murine mammary tumor virus, murine leukemia virus, L1210 leukemia-associated virus, and avian myeloblastosis virus. The simian virus resembled murine mammary tumor virus and the L1210 virus in that it produced intracytoplasmic particles that were en...
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 68 7 شماره
صفحات -
تاریخ انتشار 1971